Thalidomide-5-NH2-CH2-COOH

SKU: orb1303326

Description

Compound 114 (Thalidomide-5-NH2-CH2-COOH) is a bifunctional molecule acting as a selective protomyosin receptor kinase inhibitor and an E3 ligase ligand. It serves as a chemical probe for targeted protein degradation studies in oncology and neurological disease research, applicable in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2412056-27-8
• MW: 331.28
• Purity: 95.95% (May vary between batches)
• Formula: C₁₅H₁₃N₃O₆
• SMILES: O=C1N(C(=O)C=2C1=CC(NCC(O)=O)=CC2)C3C(=O)NC(=O)CC3
• Target: Ligands for E3 Ligase,Others
• Solubility: DMSO:3.32 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.02 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, E3 ligase, E3 ligase-recruiting Moiety, neurodegenerative, inhibit, inflammatory, infectious, Ligands for E3 Ligase, cancer, selective, tropomyosin receptor kinase, trk, Thalidomide5NH2CH2COOH, Thalidomide-5-NH-2-CH2-COOH, Thalidomide-5-NH2-CH2-COOH, Thalidomide 5 NH2 CH2 COOH, Thalidomide

Compound Identifiers

PubChem CID

146410371