Thalidomide 4-fluoride

SKU: orb1299536

Description

Thalidomide 4-fluoride is a Cereblon (CRBN)-directed E3 ligase ligand used to construct PROTAC molecules, such as PROTAC IRAK4 degrader-1. This compound enables targeted protein degradation, facilitating the study of IRAK4 signaling pathways in both cellular and biochemical research contexts.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 835616-60-9
• MW: 276.22
• Purity: 99.12% (May vary between batches)
• Formula: C₁₃H₉FN₂O₄
• SMILES: O=C1N(C(=O)C=2C1=CC=CC2F)C3C(=O)NC(=O)CC3
• Target: Autophagy,IRAK,Ligands for E3 Ligase,Apoptosis
• Solubility: DMSO:199 mg/mL (720.44 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, IRAK4, Ligand for E3 Ligase, LigandforE3Ligase, Ligands for E3 Ligase, Inhibitor, Cereblon ligand4, Cereblon ligand 4, Cereblon ligand-4, E3 ligase Ligand 4, E3 ligase-recruiting Moiety, Thalidomide 4fluoride, Thalidomide 4-fluoride, Thalidomide, Thalidomide 4 fluoride

Compound Identifiers

PubChem CID

11859051