TH9028

SKU: orb2664886

Description

TH9028 is a potent and selective small molecule inhibitor of MTHFD2, exhibiting IC50 values of 11 nM, 7.97 nM, 27 nM, and 0.5 nM against MTHFD2, hMTHFD2, MTHFD2L, and MTHFD1, respectively. This compound is a valuable research tool for studying one-carbon metabolism in cancer cell proliferation and tumor growth, applicable in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 2379556-15-5
• MW: 458.39
• Purity: 97.57% (May vary between batches)
• Formula: C₁₆H₁₈N₁₂O₅
• SMILES: N(C(NC1=C(N)NC(N)=NC1=O)=O)C=2C=CC(C(N[C@@H](CCC=3NN=NN3)C(O)=O)=O)=NC2
• Target: DHFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146197257