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TH588

SKU: orb1306674

Description

TH588

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number1609960-31-7
MW295.17
Purity99.82% (May vary between batches)
FormulaC13H12Cl2N4
SMILESNc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl
TargetDNA/RNA Synthesis|||MTH1
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.78 mM);DMSO:88.33 mg/mL (299.25 mM)

Bioactivity

Target IC50
MTH1:5 nM
In Vivo
TH588 induces DNA damage in U2OS cells, triggering ATM-p53-mediated DNA repair and apoptotic responses. It exhibits selective cytotoxicity towards U2OS and other cancer cell lines while showing minimal toxicity towards several primary or immortalized cell lines.
In Vitro
In mice carrying xenografts with the BRAFV600E mutation, TH588 (30 mg/kg, subcutaneously) reduces tumor growth rates. Additionally, in mice bearing SW480 colon or MCF7 breast cancer xenografts, TH588 (30 mg/kg, subcutaneously) inhibits MTH1, resulting in decreased tumor growth.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RNA Synthesis, RNASynthesis, TH 588, TH588, TH-588, inhibit, MTH1, Inhibitor, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 130.00
25 mg
$ 170.00
50 mg
$ 260.00
100 mg
$ 450.00
DispatchUsually dispatched within 5-10 working days
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