TH301

SKU: orb3136971

Description

TH301 acts as a stabilizer for cryptochrome circadian regulator 2 (CRY2). It demonstrates selectivity by stabilizing CRY2 over CRY1 in a degradation assay conducted with HEK293 cells expressing CRY reporters at concentrations ranging from 0.1 to 10 µM. In wild-type mouse fibroblasts, TH301 extends the circadian period, but this effect is absent in Cry2-/- fibroblasts. Additionally, it boosts rosiglitazone-dependent induction of brown adipose tissue-specific genes such as Ucp1, Cidea, and Kcnk3 in primary mouse stromal vascular fractions.

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others