TH287

SKU: orb1306570

Description

TH287 is a selective small molecule inhibitor primarily targeting the nucleotide sanitizing enzyme MTH1 (NUDT1). It exhibits lower potency against related NUDT family members. This inhibitor is a valuable research tool for studying oxidative DNA damage repair mechanisms in cancer cell lines and in vivo tumor models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1609960-30-6
• MW: 269.13
• Purity: 96.95% (May vary between batches)
• Formula: C₁₁H₁₀Cl₂N₄
• SMILES: CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl
• Target: MTH1,DNA/RNA Synthesis
• Solubility: DMSO:49 mg/mL (182.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.43 mM);Ethanol:10 mg/mL (37.16 mM)

Bioactivity

• Target IC50:
  MTH1:0.8 nM
• In Vivo:
  In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM.
• In Vitro:
  TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, MTH1, RNA Synthesis, RNASynthesis, TH287, TH-287, TH-287 Hydrochloride, TH 287, TH 287 Hydrochloride

Compound Identifiers

PubChem CID

73441664