TH1020

SKU: orb1298682

Description

TH1020 is a potent and selective small molecule inhibitor of the TLR5/flagellin interaction, exhibiting an IC50 of 0.85 µM. This compound is a valuable research tool for investigating TLR5-mediated signaling in both cellular assays and animal models of inflammation and immunity.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 1841460-82-9
• MW: 453.54
• Purity: 99.37% (May vary between batches)
• Formula: C₂₃H₁₅N₇S₂
• SMILES: C(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1
• Target: TLR,Antibacterial
• Solubility: DMSO:4.54 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  TLR5/flagellin complex:0.85 μM (IC50)
• In Vivo:
  TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation. Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TH1020, TH-1020, TH 1020, TLR5, TLR, protein-protein, Toll-like Receptor (TLR), TNF-α, inhibit, Inhibitor, interaction, flagellin, Bacterial

Compound Identifiers

PubChem CID

124203921