TH023

SKU: orb2802212

Description

TH023 is a small molecule inhibitor that selectively disrupts TLR4 homodimerization, blocking downstream NF-κB activation and inflammatory cytokine production. It demonstrates potent anti-inflammatory activity in cellular assays and in vivo models, including LPS-induced sepsis and acute lung injury, making it a valuable research tool for studying innate immunity and inflammation-related diseases.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• MW: 430.88
• Formula: C₂₂H₂₁ClF₂N₄O
• Target: TLR,Adrenergic Receptor,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR,Adrenergic Receptor,NF-κB