TH-Z93

SKU: orb1744113

Description

TH-Z93 is a lipophilic bisphosphonate compound that acts as a potent inhibitor of farnesyl pyrophosphate synthase (FPPS), with an IC50 of 90 nM. It is a valuable research tool for studying bone metabolism disorders and cancer in both cellular and animal models, as FPPS inhibition impacts osteoclast function and protein prenylation.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2260887-09-8
• MW: 368.26
• Purity: 99.99% (May vary between batches)
• Formula: C₁₂H₂₂N₂O₇P₂
• SMILES: C(NC1=CC(OCCCCCC)=CC=N1)(P(=O)(O)O)P(=O)(O)O
• Target: Antibacterial
• Solubility: H2O:1.58 mg/mL (4.29 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  TH-Z93 (20 μg; i.p.; B16-OVA cells xenograft mice mode) exhibits strong prophylactic effects in a pathogenic influenza model and Inhibits tumor growth and prolonged survival.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, THZ 93, THZ93, TH-Z93, THZ-93

Compound Identifiers

PubChem CID

134817490