TH-Z827

SKU: orb2278201

Description

TH-Z827 is a mutant-selective small molecule inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, showing no activity against KRAS(WT) or KRAS(G12C). It also disrupts the KRAS(G12D)-CRAF interaction (IC50 = 42 μM). This compound is a valuable research tool for investigating mutant-specific KRAS signaling in cancer cell-based and biochemical assays.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2847881-81-4
• MW: 498.66
• Formula: C₃₀H₃₈N₆O
• SMILES: O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168432129