TH-Z145

SKU: orb2900553

Description

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM).

Key Properties

• CAS Number: 2260887-57-6
• MW: 394.34
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₈O₇P₂
• SMILES: C(C(P(=O)(O)O)P(=O)(O)O)C1=CC(OCCCCCCCC)=CC=C1
• Solubility: In Vitro: DMSO : 100 mg/mL (253.59 mM; Ultrasonic )

Bioactivity

• In Vivo:
  TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model. Animal model: B16-OVA cells (s. c.) xenograft mice model. Dosage: 20 μg. Administration: Intraperitoneal injection (i.p.). Result: Inhibited tumor growth and prolonged survival.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only