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TH-257

SKU: orb1300045

Description

TH-257 is a potent and selective allosteric inhibitor of LIM kinase 1 and 2 (LIMK1/2), exhibiting IC50 values of 84 nM and 39 nM, respectively. This small molecule is a valuable research tool for investigating cytoskeletal dynamics in cellular models and has been utilized in studies exploring cancer cell metastasis and neuronal morphology.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2244678-29-1
MW422.54
Purity98.23% (May vary between batches)
FormulaC24H26N2O3S
SMILESCCCCN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1
TargetLIM Kinase
SolubilityDMSO:250 mg/mL (591.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.83 mM)

Bioactivity

Target IC50
LIMK1:84 nM|LIMK2:39 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TH257, TH-257, TH 257, Inhibitor, inhibit, LIMKs, LIMKinase, LIM Kinase, LIM Kinase (LIMK)

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Quality Guarantee

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Key Properties

No computed properties available.

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TH-257 (orb1300045)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 240.00
100 mg
$ 360.00
200 mg
$ 500.00
DispatchUsually dispatched within 3-5 working days
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