TGX-221

SKU: orb1224301

Description

A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM; weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM); inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding; shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.

Key Properties

• CAS Number: 663619-89-4
• MW: 364.4409
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₄N₄O₂
• SMILES: O=C1C=C(N2CCOCC2)N=C3N1C=C(C)C=C3C(NC4=CC=CC=C4)C
• Target: PI3K
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TGX221 | TGX 221

Quick Database Links

Gene Symbol

PI3K