TG 100713

SKU: orb1300539

Description

TG 100713 is a potent pan-phosphoinositide 3-kinase (PI3K) inhibitor, exhibiting IC50 values of 50 nM (PI3Kγ), 24 nM (PI3Kδ), 165 nM (PI3Kα), and 215 nM (PI3Kβ). This small molecule is a valuable research tool for studying PI3K signaling in inflammation and oncology, with applications in both cellular and animal model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 925705-73-3
• MW: 254.25
• Purity: 99.91% (May vary between batches)
• Formula: C₁₂H₁₀N₆O
• SMILES: Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
• Target: PI3K
• Solubility: DMSO:2.57 mg/mL (10.11 mM)

Bioactivity

• Target IC50:
  PI3Kγ:50 nM|PI3Kα:165 nM|PI3Kβ:215 nM|PI3Kδ:24 nM
• In Vitro:
  TG 100713 also strongly inhibits EC proliferation.
• Cell Research:
  Human umbilical vein EC plated in 96-well cluster plates (5,000 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of test compounds (10 μM), and cell numbers are quantified by XTT assay.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TG100713, TG-100713, TG 100713, PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, PI3K, Phosphoinositide 3-kinase, inhibit, Inhibitor, isoform

Compound Identifiers

PubChem CID

17751063