TFGF-18

SKU: orb2814059

Description

TFGF-18 is a potent GSK-3β inhibitor (IC50 = 0.59 µM) that attenuates neuroinflammation by suppressing microglial activation and NF-κB signaling. It provides neuroprotection in models of cognitive impairment by reducing neuronal apoptosis and oxidative stress, making it a valuable research tool for studying neurodegenerative and inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2222662-20-4
• MW: 613.53
• Formula: C₂₈H₃₀F₃NO₁₁
• SMILES: O(C)C=1C(=C(OC)C=C2C1C(=O)C=C(O2)C3=CC(OC)=C(OC)C=C3)[C@@H]4O[C@H](C(N[C@H](C(F)(F)F)C)=O)[C@@H](O)[C@H](O)[C@H]4O
• Target: Caspase,Bcl-2 Family,GSK-3,Reactive Oxygen Species,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155210417