Tetrandrine

SKU: orb1304758

Description

Tetrandrine

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 518-34-3
• MW: 622.75
• Purity: 99.84%
• Formula: C₃₈H₄₂N₂O₆
• SMILES: O(C)C1=C2C=3[C@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H]
• Target: Potassium Channel,Calcium Channel,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.7 mg/mL (1.12 mM);DMSO:12.45 mg/mL (19.99 mM)

Bioactivity

• In Vivo:
  METHODS: To detect anti-tumor activity in vivo athymic nude mice bearing THP-1 xenografts were administered Tet andrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. Results: Tet andrine treatment reduced tumor growth.
• In Vitro:
  METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tet andrine (1-3 µM) for 24-72 h, and cell numbers were measured. Results: 2 µM and 3 µM Tet andrine significantly inhibited cell proliferation. METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tet andrine (5 µM) for 16 h and GFP-LC3 spots were detected. Results: Tet andrine significantly induced GFP-LC3 spot formation with similar potency (5 µM) in All cell lines tested.Tet andrine induced autophagy in multiple cell lines.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Ca2+ channels, Calcium Channel, Ca channels, d-Tetrandrine, CalciumChannel, Inhibitor, Fanchinine, Hanfangchin A, KcsA, inhibit, NSC 77037, NSC77037, NSC-77037, Tetrandrine, Potassium Channel, PotassiumChannel, Sinomenine A

Compound Identifiers

PubChem CID

73078