Tetramethylkaempferol

SKU: orb1297062

Description

Tetramethylkaempferol is a PPARγ agonist that enhances insulin sensitivity via adiponectin upregulation and promotes adipogenic triglyceride accumulation. This compound is a useful research tool for studying metabolic disorders, including diabetes and obesity, in both cellular and animal models.

Research Area

Infectious Disease & Virology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 16692-52-7
• MW: 342.34
• Purity: 99.65% (May vary between batches)
• Formula: C₁₉H₁₈O₆
• SMILES: O(C)C1=C2C(OC(=C(OC)C2=O)C3=CC=C(OC)C=C3)=CC(OC)=C1
• Target: transporter,PPAR,Antifungal
• Solubility: Acetonitrile:13.69 mg/mL (39.99 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.92 mM);DMSO:27.22 mg/mL (79.51 mM)

Bioactivity

• In Vitro:
  Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GLUT, Tetramethylkaempferol, PPAR

Compound Identifiers

PubChem CID

631095