Tetrahydropapaverine hydrochloride

SKU: orb1301202

Description

Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) is a neurotoxic tetrahydroisoquinoline alkaloid structurally related to salsolinol and tetrahydropapaveroline. It is used in neuroscience research to study selective dopaminergic neurotoxicity and mechanisms of Parkinson's disease in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 6429-04-5
• MW: 379.878
• Purity: 99.83%
• Formula: C₂₀H₂₆ClNO₄
• SMILES: Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
• Target: Others,Hydroxylase
• Solubility: DMSO:60 mg/mL (157.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

• Target IC50:
  TPH:5.7 μM
• In Vivo:
  In mouse mastocytoma P815 cells involved in serotonin production, Tetrahydropapaverine can inhibit serotonin biosynthesis (IC50: 7.5 μM) and reduce tryptophan hydroxylase activity (IC50: 5.7 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Norlaudanosine HCl, inhibit, Inhibitor, Tryptophan hydroxylase, Tetrahydroalkali hydrochloride, Tetrahydroalkali Hydrochloride, Tetrahydroisoquinolines, Tetrahydropapaverine, Tetrahydropapaverine HCl, Tetrahydropapaverine hydrochloride, Tetrahydropapaverine Hydrochloride

Compound Identifiers

PubChem CID

16667431