Tetradecylthioacetic acid

SKU: orb1297866

Description

Tetradecylthioacetic acid

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 2921-20-2
• MW: 288.49
• Purity: ≥98% (May vary between batches)
• Formula: C₁₆H₃₂O₂S
• SMILES: CCCCCCCCCCCCCCSCC(O)=O
• Target: PPAR
• Solubility: DMSO:60 mg/mL (207.98 mM)

Bioactivity

• In Vivo:
  Mice receiving HFD supplemented with 0.75% (w/w) TTA had significantly lower body weights compared to mice fed the diet without TTA. Plasma triacylglycerol (TAG) was reduced 3-fold with TTA treatment, concurrent with increase in liver TAG. Total cholesterol was unchanged in plasma and liver. However, TTA promoted a shift in the plasma lipoprotein fractions with an increase in larger HDL particles. Histological analysis of the small intestine revealed a reduced size of lipid droplets in enterocytes of TTA treated mice, accompanied by increased mRNA expression of fatty acid transporter genes. Expression of the cholesterol efflux pump Abca1 was induced in the small intestine, but not in the liver. Scd1 displayed markedly increased mRNA and protein expression in the intestine of the TTA group.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-(Tetradecylthio)acetic acid, inhibit, hypolipidemia, Inhibitor, fatty acid oxidation, PPAR, Peroxisome proliferator-activated receptors, Tetradecylthioacetic acid, β-Oxidation

Compound Identifiers

PubChem CID

114924