Terevalefim

SKU: orb1303787

Description

Terevalefim

Research Area

Signal Transduction

Key Properties

• CAS Number: 1070881-42-3
• MW: 176.24
• Purity: 99.80% (May vary between batches)
• Formula: C₉H₈N₂S
• SMILES: C(=C/c1cccs1)\c1cc[nH]n1
• Target: c-Met/HGFR
• Solubility: DMSO:100 mg/mL (567.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (22.7 mM)

Bioactivity

• In Vivo:
  Terevalefim (ANG-3777) reduces apoptosis, enhances proliferation, and supports organ repair and function in animal models. Additionally, Terevalefim (ANG-3777, 40 mg/kg, IP) induces phosphorylation of the c-Met receptor in rats.
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• In Vitro:
  Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cell proliferation in HUVECs.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cMet, c-Met, c-Met/HGFR, cMet/HGFR, acute, AKI, ANG 3777, ANG3777, ANG-3777, injury, Inhibitor, HGFR, HGF, inhibit, kidney, Terevalefim, transplantation

Compound Identifiers

PubChem CID

5714038