Terconazole

SKU: orb1306085

Description

Terconazole is a synthetic triazole antifungal agent that inhibits ergosterol biosynthesis, compromising fungal membrane integrity and leading to cell death. It is used in research to study antifungal mechanisms and efficacy against Candida species in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 67915-31-5
• MW: 532.46
• Purity: 99.94% (May vary between batches)
• Formula: C₂₆H₃₁Cl₂N₅O₃
• SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)C)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=NC=N5
• Target: Antifection,Antifungal
• Solubility: DMSO:50 mg/mL (93.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.76 mM)

Bioactivity

• In Vivo:
  A three-day, once-daily, intravaginal administration of 0.8% terconazole typically ensures a functional therapeutic duration of seven days, owing to sustained, elevated levels of the biologically active antifungal in the vagina. Terconazole is well-tolerated, with no side effects reported at any concentration.
• In Vitro:
  Terconazole effectively inhibits the growth of Candida albicans ATCC 44859 in a concentration-dependent manner, demonstrating limited effects at 0.1 to 10 μM when cultured on media promoting the cell form. Its inhibitory impact on yeast cell viability varies across different Candida strains and species. Notably, C. albicans ATCC 44859's susceptibility to terconazole significantly increases on Eagle minimum essential medium, which encourages mycelium formation. The effects of terconazole range from inhibiting mycelia development at 0.1 μM to causing complete necrosis at 100 μM. Moreover, terconazole prevents the morphogenetic shift from the yeast to the filamentous form at concentrations between 0.008 and 0.05 microgram/mL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R 42470, R42470, R-42470, Triaconazole, Terazol 3, Terazol 7, Terconazole, 14-α Demethylase, Gyno-Terazol, Fungal, Inhibitor, inhibit

Compound Identifiers

PubChem CID

441383