Terbuthylazine

SKU: orb1708380

Description

Terbuthylazine is a triazine-class ALS inhibitor herbicide used in agricultural and environmental toxicity research. It is employed in in vitro and in vivo studies to investigate its toxicological effects, including aquatic toxicity, disruption of gut microbiota, and damage to the intestinal barrier and mitochondrial function.

Key Properties

• CAS Number: 5915-41-3
• MW: 229.71
• Purity: 99.07% (May vary between batches)
• Formula: C₉H₁₆ClN₅
• SMILES: ClC=1N=C(N=C(N1)NC(C)(C)C)NCC
• Target: Others
• Solubility: DMSO:40 mg/mL (174.13 mM);10% DMSO+90% Corn Oil:2 mg/mL (8.71 mM)

Bioactivity

• In Vivo:
  Terbuthylazine (0.4 mg/kg) exposure caused cardiomyopathic rational changes in broilers. Terbuthylazine (0.4 or 4 mg/kg, 28 days) broilers showed pathological damage such as widening of interstitial space, breaking of muscle fibers, and deposition of myocardial collagen fibers.
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• In Vitro:
  Terbuthylazine induces innate immune response and inflammation by activating the cGAS-STING/NF-κB pathway in broiler heart muscle. Terbuthylazine exposure activates the Nrf2/HO-1 pathway, leading to iron death.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Terbuthylazine

Compound Identifiers

PubChem CID

22206