Terameprocol

SKU: orb1306216

Description

Terameprocol (EM-1421) is a methylated NDGA derivative that acts as a transcriptional inhibitor. It exhibits potent anti-HIV activity alongside studied antiangiogenic and antineoplastic properties, supporting its investigation in both in vitro and in vivo cancer and virology research models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 24150-24-1
• MW: 358.47
• Purity: 99.79% (May vary between batches)
• Formula: C₂₂H₃₀O₄
• SMILES: COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
• Target: Survivin,Apoptosis,COX,Lipoxygenase,TNF,HIV Protease
• Solubility: DMSO:27.5 mg/mL (76.71 mM)

Bioactivity

• In Vivo:
  Terameprocol effectively inhibited the growth of human tumors in nude mice . Terameprocol inhibited the growth of both murine and human melanomas and human colon cancer without apparent hepatic or renal toxicity . In nude (nu/nu) mice bearing xenografts of human tumor types (Hep 3B, LNCaP, HT-29, MCF7, and K-562), treatment with Terameprocol (i.v. or i.p.) down-regulated Cdc2 and survivin genes expression .
• In Vitro:
  In Vero cells, Terameprocol inhibited Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter with IC50 values of 11 and 43.5 μM, respectively. The IC50 of Terameprocol varied between 11.7 and 4 μM in 10 passages of HSV-1 and 4 passages of HSV-2 . Terameprocol inhibited Sp1-dependent Cdc2 gene expression. In M4N-treated transformed C3 cells, Terameprocol induced growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity . Terameprocol treatment suppressed expression of the Sp1-dependent survivin gene. In transiently and stably survivin-transfected C3 cells, Terameprocol reduced caspase-3 activation by 50% and 75%, respectively . Terameprocol inhibited the growth of a number of tumor cell lines by inducing apoptosis in a non-schedule-dependent manner . Terameprocol inhibited the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EM1421, EM-1421, EM 1421, Inhibitor, HIV, HIV Protease, HIVProtease, LOX, Lipoxygenase, inhibit, Terameprocol, tetramethyl Nordihydroguaiaretic Acid

Compound Identifiers

PubChem CID

476861