Teplinovivint

SKU: orb1298327

Description

Teplinovivint is a small molecule Wnt/β-catenin pathway inhibitor with demonstrated anti-inflammatory effects. It is a valuable research tool for investigating tendinopathy mechanisms and therapeutic strategies in both in vitro cell-based assays and in vivo animal models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1428064-91-8
• MW: 442.51
• Purity: 97.21% (May vary between batches)
• Formula: C₂₅H₂₆N₆O₂
• SMILES: COc1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCCCC3)c2)cn1
• Target: Wnt/beta-catenin
• Solubility: DMSO:83.33 mg/mL (188.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.46 mM)

Bioactivity

• In Vivo:
  Teplinovivint (1 mg/ml with 1% BA) has a Tmax of 1 hours in plasma. Teplinovivint (10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model.
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• In Vitro:
  Teplinovivint (5.8, 10.8, 21.7, 41.7, 83.3, 166.6, 333.3, 750 nM) induced the expression of SCXA, TenacinC and Tenomodulin, in a dose-dependent manner with an EC50 between 139-189 nM. Teplinovivint (compound 175; 0.0003-10 μM) inhibits Wnt/p-catenin activity in human colorectal cancecell line (SW480) in a dose-dependent manner (EC50=152.9 nM). Teplinovivint inhibits SW480 cells (EC50=25 nM) and primary human mesenchymal stem cells (hMSCs; EC50=10.377 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, mesenchymal, Inhibitor, hMSCs, bcatenin, colorectal, Beta catenin, betacatenin, beta-catenin, SCXA, stem, SW480, Wnt, wnt/β-catenin, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, Teplinovivint, Tenomodulin, TenacinC, β-catenin, βcatenin

Compound Identifiers

PubChem CID

89451003