Tenovin-6 Hydrochloride

SKU: orb1298898

Description

Tenovin-6 Hydrochloride is a small molecule inhibitor of SIRT1, SIRT2, and HDAC8 with reported IC50 values of 21 μM, 10 μM, and 67 μM, respectively. It functions as a p53 activator and has been utilized in both in vitro and in vivo cancer research studies to investigate pathways involving apoptosis and cellular senescence.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1011301-29-3
• MW: 491.09
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₃₅ClN₄O₂S
• SMILES: Cl.CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
• Target: Sirtuin,HDAC,MDM-2/p53,p53,Dehydrogenase,Autophagy
• Solubility: DMSO:45 mg/mL (91.63 mM)

Bioactivity

• Target IC50:
  SIRT2:10 μM|SIRT1:21 μM|SIRT3:67 μM
• In Vitro:
  Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS). Tenovin-6 inhibited the growth of UM cells. Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270. Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells. In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs.tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC8, Inhibitor, MDM2, MDM-2/p53, inhibit, p53, Autophagy, acetylation, degradation, DHODH, Dihydroorotate Dehydrogenase, protein-deacetylating, SIRT2, SIRT1, Sirtuin, SIRT3, Tenovin6, Tenovin-6, Tenovin6 Hydrochloride, Tenovin-6 Hydrochloride, Tenovin 6, Tenovin 6 Hydrochloride

Compound Identifiers

PubChem CID

49871498