Tenovin-1

SKU: orb1307110

Description

Tenovin-1 is a small molecule inhibitor of the deacetylase enzymes SirT1 and SirT2. It stabilizes p53 by blocking its MDM2-mediated ubiquitination and degradation, making it a valuable tool for cancer research in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 380315-80-0
• MW: 369.5
• Purity: >98%
• Formula: C₂₀H₂₃N₃O₂S
• SMILES: CC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
• Target: Protein deacetylase
• Solubility: Soluble in DMSO (up tp 10 mg/ml, warm)

Bioactivity

• In Vivo:
  Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels.
• In Vitro:
  Tenovin-1 (10 μM) protected p53 from mdm 2-mediated degradation, but had little effect on p53 protein synthesis. When applied to p53-expressing tumor cells, Tenovin-1 inhibited cell growth and induced apoptosis.Tenovin-1 is a p53 activator and increased the amount of p53 protein within 2 h of treatment.Tenovin-1 did not affect p53 mRNA levels.
• Cell Research:
  Cell viability isdetermined by trypan blue exclusion, Giemsa staining, or MTT assays.(Only for Reference)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODH, degradation, Dihydroorotate Dehydrogenase, acetylation, Autophagy, inhibit, p53, Inhibitor, MDM2, Mdm2, MDM-2/p53, Tenovin 1, Tenovin1, Tenovin-1, protein-deacetylating, Sirtuin

Compound Identifiers

PubChem CID

1013376