Tenofovir alafenamide

SKU: orb1305529

Description

Tenofovir alafenamide

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 379270-37-8
• MW: 476.47
• Purity: 99.97% (May vary between batches)
• Formula: C₂₁H₂₉N₆O₅P
• SMILES: CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)Oc1ccccc1
• Target: HIV Protease,Reverse Transcriptase
• Solubility: Ethanol:88 mg/mL (184.69 mM);DMSO:70 mg/mL (146.91 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.2 mM)

Bioactivity

• In Vivo:
  In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue.
• In Vitro:
  Tenofovir alafenamide has a potent anti-HIV activity with IC50 of 0.005 μM. GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. the hepatic uptake of Tenofovir alafenamide isfacilitated by OATP1B1 and OATP1B3, respectively. Tenofovir alafenamide inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, GS-7340, GS7340, GS 7340, Human immunodeficiency virus, Inhibitor, HIV, HIV Protease, HIVProtease, ReverseTranscriptase, Reverse Transcriptase, Tenofovir alafenamide

Compound Identifiers

PubChem CID

9574768