Tenilsetam

SKU: orb1298811

Description

Tenilsetam is a piperazinone-derived small molecule with nootropic properties, acting as an endonuclease modulator and AGE inhibitor. It is utilized in Alzheimer's disease research, with studies investigating its neuroprotective effects in both cellular and animal models of cognitive decline.

Research Area

Cell Biology

Key Properties

• CAS Number: 86696-86-8
• MW: 182.243
• Purity: 99.88% (May vary between batches)
• Formula: C₈H₁₀N₂OS
• SMILES: O=C1NCCNC1C1=CC=CS1
• Target: TNF,Others
• Solubility: DMSO:25 mg/mL (137.18 mM)

Bioactivity

• In Vitro:
  In vitro, tenilsetam inhibited endothelial proliferation at lower doses, while inducing apoptosis at high doses. Leucocyte adhesion was only inhibited at high doses. Sprouting angiogenesis of bovine retinal endothelial cells was promoted at lower doses (< or = 10 mM). At micromolar concentrations, endothelial VEGF expression was upregulated by 100%. Long-term treatment with the AGE-inhibitor and iron-chelating compound tenilsetam inhibits the formation of acellular capillaries without correcting pericyte loss. The compound has dose-dependent effects on endothelial cell function.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tenilsetam, Piperazinone, 3-(2-thienyl)-, AGE

Compound Identifiers

PubChem CID

65649