Tenatoprazole

SKU: orb1300543

Description

Tenatoprazole (TU-199) is a prodrug belonging to the proton pump inhibitor class, demonstrating inhibitory activity against proton transport with an IC50 of 3.2 µM. This compound is utilized in biochemical research to investigate gastric acid secretion mechanisms and has been applied in both in vitro assays and in vivo pharmacological studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 113712-98-4
• MW: 346.4
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₈N₄O₃S
• SMILES: COc1ccc2[nH]c(nc2n1)S(=O)Cc1ncc(C)c(OC)c1C
• Target: Proton pump
• Solubility: DMSO:11 mg/mL (31.76 mM);Ethanol:12 mg/mL (34.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.77 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Proton transport:3.2 μM
• In Vivo:
  Tenatoprazole provides slow activation in vivo, which is predicted by its chemical activation rate in fasting rats. Tenatoprazole inhibits about 20–30% of enzyme activity even though acid secretion in fasting rats. (S)-tenatoprazole sodium salt hydrate provides a higher Cmax of 183 ng/mL, Tmax of 1.3 hours and AUC of 822 ng*h/mL in dog.
• In Vitro:
  Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

oral, secretion, inhibit, Inhibitor, gastric, acid, ATPase, Proton Pump, Proton pump, Protonpump, TU 199, TU199, TU-199, Tsg101, Tenatoprazole, virus

Compound Identifiers

PubChem CID

636411