Telratolimod

SKU: orb1940690

Description

Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.(In Vivo):Telratolimod (50 μg) suppresses the tumor volume and more effectively blocks tumor growth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs the survival of mice bearing large tumors .

Key Properties

• CAS Number: 1359993-59-1
• MW: 593.901
• Purity: >98% (HPLC)
• Formula: C₃₆H₅₉N₅O₂
• SMILES: CCCCCCCCCCCCCCCCCC(=O)NCCCCOn1c(CCCC)nc2c(N)nc3ccccc3c12
• Target: TLR
• Solubility: In Vitro: DMSO : 62.5 mg/mL (105.24 mM)

Bioactivity

• In Vivo:
  Telratolimod (50 μg) inhibits the tumor volume, and more potently blocks tumor gowth in combination with CpG ODN in BALB/c mice bearing CT26 colon carcinoma cells. Telratolimod (100 μg) plus 200 μg of CpG ODN slows tumor growth and prolongs survival of mice bearing large tumors.
• In Vitro:
  Telratolimod (3M-052) is a toll like receptors 7/8 (TLR7/8) agonist, with antitumor activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEDI9197 | 3M-052

Quick Database Links

Gene Symbol

TLR