Tellimagrandin II

SKU: orb1690241

Description

Tellimagrandin II is an orally bioavailable natural product with dual activity against methicillin-resistant Staphylococcus aureus (MRSA) and acetylcholinesterase (AChE). It has shown efficacy in both in vitro antimicrobial assays and in vivo models for improving memory impairment, making it a compound of interest for infectious disease and neuroscience research.

Research Area

Infectious Disease & Virology, Neuroscience

Key Properties

• CAS Number: 81571-72-4
• MW: 938.67
• Purity: 99.18% (May vary between batches)
• Formula: C₄₁H₃₀O₂₆
• SMILES: O=C(OC1OC2COC(=O)C=3C=C(O)C(O)=C(O)C3C4=C(O)C(O)=C(O)C=C4C(=O)OC2C(OC(=O)C5=CC(O)=C(O)C(O)=C5)C1OC(=O)C6=CC(O)=C(O)C(O)=C6)C7=CC(O)=C(O)C(O)=C7
• Target: Antibacterial,Cholinesterase (ChE)
• Solubility: DMSO:80.00 mg/mL (85.23 mM)

Bioactivity

• In Vivo:
  In the scopolamine-induced amnesic ICR mouse model, Tellimagrandin II (100 and 200 mg/kg, p.o., once daily for 10 days) significantly improved learning and memory functions in the passive avoidance test and water maze test .
• In Vitro:
  Treatment with Tellimagrandin II at a concentration of 40 µg/mL for 24 hours can disrupt the cell wall integrity of Staphylococcus aureus . In methicillin-resistant Staphylococcus aureus, treatment with Tellimagrandin II (40 µg/mL) for 5 hours significantly reduces the transcriptional level of the mecA gene and the expression of PBP2a protein . In RAW264.7 macrophages, Tellimagrandin II (50 μM) treatment for 6 hours markedly inhibits LPS-induced nitric oxide production and downregulates the mRNA and protein expression of NOS2 . Treatment with Tellimagrandin II (25 or 50 μM) for 12 hours effectively reduces LPS-stimulated COX-2 protein expression and prostaglandin E2 synthesis in RAW264.7 macrophages . Tellimagrandin II (12.5-50 μM) exhibits significant inhibitory activity against acetylcholinesterase after 10 minutes of incubation, with an IC50 value of 18.6 μM .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tellimagrandin II, Eugeniin

Compound Identifiers

PubChem CID

151590