Telbivudine

SKU: orb1308383

Description

Telbivudine

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3424-98-4
• MW: 242.23
• Purity: 99.98% (May vary between batches)
• Formula: C₁₀H₁₄N₂O₅
• SMILES: Cc1cn([C@@H]2C[C@@H](O)[C@H](CO)O2)c(=O)[nH]c1=O
• Target: Reverse Transcriptase,HBV
• Solubility: H2O:44 mg/mL (181.65 mM);DMSO:50 mg/mL (206.42 mM);Ethanol:2 mg/mL (8.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (10.32 mM)

Bioactivity

• In Vivo:
  Telbivudine significantly increases the levels of tumor necrosis factor-alpha and interleukin-2 in macrophages (induced by MHV-3) as well as serum levels of interferon-gamma. It is phosphorylated by cellular thymidine kinase into an active triphosphate form, with an intracellular half-life of 14 hours. While enhancing the proliferation and secretion capabilities of T-cells, Telbivudine does not affect the cytotoxicity against infected hepatocytes. Furthermore, it inhibits the expression of programmed death ligand 1 in T-cells. Despite mutations such as N236T and A181V/A194T, Telbivudine remains active at increased magnitudes of 0.5 and 1.0 times, respectively. The differences in resistance between lamivudine and Telbivudine are due to Telbivudine's inactivity against the lamivudine-resistant HBV strain L180M/M204V/I mutation, though it remains active against the M204V single mutation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, L-Thymidine, NV 02B, HBV, Hepatitis B virus, Epavudine, Reverse Transcriptase, ReverseTranscriptase, Protein P, Telbivudine

Compound Identifiers

PubChem CID

159269