Teglarinad chloride

SKU: orb1701538

Description

Teglarinad chloride (GMX-1777 chloride) is a small molecule NAMPT inhibitor with demonstrated antitumor properties. Its mechanism involves disrupting DNA repair processes and suppressing angiogenesis, as evidenced in both in vitro and in vivo cancer research models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 432037-57-5
• MW: 672.6
• Purity: 98.09% (May vary between batches)
• Formula: C₃₀H₄₃Cl₂N₅O₈
• SMILES: [Cl-].COCCOCCOCCOCCOC(=O)OC[n+]1ccc(N\C(NC#N)=N/CCCCCCOc2ccc(Cl)cc2)cc1
• Target: NAMPT

Bioactivity

• In Vivo:
  In the IM-9 model, small-cell lung cancer (SHP-77) model, and colon carcinoma (HCT-116) model, GMX1777 (75 mg/kg; 24 h intravenous infusion) induces tumor regression.For both FaDu and C666-1 tumors in vivo, GMX1777 (50-100 mg/kg/day, intramuscular for 5 days), with or without local tumor radiotherapy, proves to be effective.Upon intravenous infusion (25-400 mg/kg; 24 h), GMX1777 is rapidly converted to GMX1778 in the plasma of mice, with a half-life of GMX1777 less than 0.7 h.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EB1627 chloride, EB-1627 chloride, EB 1627, GMX 1777 chloride, GMX-1777, GMX1777 chloride, GMX-1777 chloride, NAMPT

Compound Identifiers

PubChem CID

9961434