Tedizolid Phosphate

SKU: orb1300274

Description

Tedizolid phosphate (TR-701 FA) is a prodrug of the oxazolidinone antibiotic tedizolid. It is used in research to investigate its potent antibacterial activity against Gram-positive pathogens, including MRSA, in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Neuroscience

Key Properties

• CAS Number: 856867-55-5
• MW: 450.32
• Purity: 99.84% (May vary between batches)
• Formula: C₁₇H₁₆FN₆O₆P
• SMILES: Cn1nnc(n1)-c1ccc(cn1)-c1ccc(cc1F)N1C[C@H](COP(O)(O)=O)OC1=O
• Target: Monoamine Oxidase,Antibiotic,Antibacterial
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.22 mM);DMSO:1 mg/mL (2.22 mM)

Bioactivity

• In Vivo:
  Tedizolid has excellent penetration into pulmonary epithelial lining fluid (ELF). Tedizolid phosphate administered to mice orally or intravenously is effective in vivo against systemic infection with PRSP isolates. Oral tedizolid phosphate is also effective in vivo against pneumonia induced with a PSSP strain.
• In Vitro:
  Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA). Tedizolid is 4-fold more potent than linezolid against PRSP isolates in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tedizolid Phosphate, Tedizolid, TR-701FA, Torezolid Phosphate, Torezolid phosphate, inhibit, Inhibitor, Bacterial, antibiotic, Antibiotic

Compound Identifiers

PubChem CID

11476460