Tedizolid Phosphate

SKU: orb1223026

Description

Tedizolid is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.(In Vitro):Tedizolid phosphate (TR-701FA; 0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP.(In Vivo):For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate (TR-701FA) at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 856867-55-5
• MW: 450.32
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₆FN₆O₆P
• SMILES: CN1N=NC(=N1)C1=NC=C(C=C1)C1=CC=C(C=C1F)N1C[C@H](COP(O)(O)=O)OC1=O
• Target: Amino Acids and Derivatives
• Solubility: DMSO : ≥ 36 mg/mL. 79.94 mM. H2O : 0.1 mg/mL0.22 mM

Bioactivity

• In Vivo:
  For mice infected with PSSP type III, the 100% survival rate is achieved with tedizolid phosphate (TR-701FA) at a minimum total daily dose of 10 mg/kg. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema.
• In Vitro:
  Tedizolid phosphate (TR-701FA; 0.25 μg/mL) inhibits all 28 clinical isolates of PRSP, and is 4-fold more potent than linezolid against PRSP.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TR-701FA

Quick Database Links

Gene Symbol

Amino Acids and Derivatives