Tedizolid

SKU: orb1307549

Description

Tedizolid (DA-7157) is a next-generation oxazolidinone antibiotic that acts by binding to the bacterial 50S ribosomal subunit, thereby inhibiting protein synthesis. It is widely used in research for investigating Gram-positive infections, demonstrating efficacy in both in vitro antimicrobial studies and in vivo animal models of infection.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 856866-72-3
• MW: 370.34
• Purity: 99.89%
• Formula: C₁₇H₁₅FN₆O₃
• SMILES: O=C1N(C[C@H](CO)O1)C2=CC(F)=C(C=C2)C=3C=CC(=NC3)C4=NN(C)N=N4
• Target: MAO,Antibacterial,Antibiotic
• Solubility: DMSO:2.8 mg/mL (7.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.7 mM)

Bioactivity

• In Vivo:
  The tedizolid phosphate at a minimum total daily dose of 10 mg/kg achieved a 100% survival rate for mice infected with PSSP type III. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema.
• In Vitro:
  Tedizolid (0.25 μg/mL) effectively inhibits all 28 clinical isolates of PRSP, demonstrating a potency four times greater than linezolid against PRSP.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tedizolid, TR700, TR-700, TR 700, Torezolid, DA7157, DA-7157, DA 7157, Antibiotic, Bacterial, Inhibitor, MAO-A, MAO-B, inhibit

Compound Identifiers

PubChem CID

11234049