TED-347

SKU: orb1220133

Description

TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.

Key Properties

• CAS Number: 2378626-29-8
• MW: 313.7
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₁ClF₃NO
• SMILES: FC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
• Target: TEAD4-Yap1
• Solubility: DMSO:64 mg/ml(204.02 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: GBM43 glioblastoma cell lines. Concentration: 0.5, 1, 10, 100 μM Incubation time: 48 hours. Result: Inhibited GBM43 cancer cell viability and inhibited GBM43 cell viability by 30% at 10 μM. Western blot analysis. Cell line: HEK-293 cells. Concentration: 5 μM. Incubation time: 48 hours. Result: Showed a significant loss of co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged Yap1.RT-PCR Cell line: HEK-293 cells. Concentration: 10 μM. Incubation time: 48 hours. Result: Showed a significant reduction in CTGF transcript levels versus control cells and had no inhibition on TEAD mutant transcriptional activity and protein-protein interactions in cell culture.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TEAD4-Yap1