Tectol

SKU: orb1297040

Description

Tectol is a moderately active antiplasmodial and antiproliferative small molecule (IC50 = 3.44±0.20 µM), showing significant activity against HL60 and CEM leukemia cell lines in vitro. It has been investigated for antimalarial and anticancer research. A reported side effect is itchy dermatitis on the neck, trunk, and limbs.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 24449-39-6
• MW: 450.52
• Purity: 99.23% (May vary between batches)
• Formula: C₃₀H₂₆O₄
• SMILES: CC1(C)Oc2c(C=C1)c(c(O)c1ccccc21)-c1c(O)c2ccccc2c2OC(C)(C)C=Cc12
• Target: Transferase,Parasite
• Solubility: 10% DMSO+90% Corn Oil:1.67 mg/mL (3.71 mM);DMSO:55 mg/mL (122.08 mM)

Bioactivity

• Target IC50:
  FTase:3.44±0.20μM
• In Vitro:
  Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone , were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only Tectol and lippsidoquinone exhibited significant activity against human leukemia cell lines HL60 and CEM.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-malarial, cell, drug-resistant, cytotoxic, HL60, leukemia, Farnesyl Transferase, Farnesyl transferase (FTase), Ftase, Parasite, lines, inhibit, Inhibitor, Tectol

Compound Identifiers

PubChem CID

161453