TEAD1/3/4-IN-1

SKU: orb3027377

Description

TEAD1/3/4-IN-1 (compound 1) is an inhibitor of TEAD1/3/4 that suppresses YAP/TAZ-TEAD interactions. It exhibits antitumour activity against NF2-deficient NCI-H226 cells and may be employed in studies of cancer and diseases mediated by Hippo pathway abnormalities.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2762619-63-4
• MW: 407.32
• Purity: 99.25% (May vary between batches)
• Formula: C₁₈H₁₃F₄N₅O₂
• SMILES: O=C(C(F)=C)N1CC(N2C(=O)N(C3=CC=C(C=C3)C(F)(F)F)C4=NC=CN=C42)C1
• Target: YAP
• Solubility: DMSO:20 mg/mL (49.1 mM);10% DMSO+90% Corn Oil:2 mg/mL (4.91 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TEAD1/3/4IN1

Quick Database Links

Gene Symbol

YAP