TEAD-IN-12

SKU: orb2564418

Description

TEAD-IN-12 (58B) is a potent, orally bioavailable small molecule inhibitor of the TEAD transcription factors, with sub-100 nM IC₅₀ activity and a 3.6-hour half-life in mice. It is a valuable chemical probe for investigating the Hippo signaling pathway in cancer research, enabling both in vitro mechanistic studies and in vivo efficacy models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3034813-66-3
• MW: 431.41
• Formula: C₂₂H₂₀F₃N₃O₃
• SMILES: C(=O)([C@@H]1[C@H](C1)C=2C=3C(C=C(OC4=CC=C(C(F)(F)F)C=C4)C2)=CN(C)N3)N5CC(O)C5
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171590523