TDI-011536

SKU: orb1689811

Description

TDI-011536 is a potent and selective LATS1/2 kinase inhibitor that disrupts the Hippo signaling pathway, leading to YAP activation. It is a valuable research tool for studying cardiac regeneration, promoting cardiomyocyte proliferation in vitro and in models of myocardial injury in vivo.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2687970-96-1
• MW: 364.42
• Purity: 99.83% (May vary between batches)
• Formula: C₁₉H₁₆N₄O₂S
• SMILES: OCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1
• Target: YAP,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM);DMSO:33.93 mg/mL (93.11 mM)

Bioactivity

• In Vivo:
  TDI-011536 (200 mg/kg; i.p.; once) inhibits Lats and reduces pYap levels for over 4 hours in the liver, heart, and skin, while TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) exhibits a proliferative effect on cardiomyocytes.
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• In Vitro:
  TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces Müller glia proliferation in human retinal organoids.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TDI 011536, TDI011536, TDI-011536

Compound Identifiers

PubChem CID

156824399