TD52 dihydrochloride

SKU: orb1694540

Description

TD52 dihydrochloride

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• MW: 433.33
• Purity: 98.46% (May vary between batches)
• Formula: C₂₄H₁₈Cl₂N₄
• SMILES: C#CC1=CC=CC(NC2=NC3=C(N=C2NC4=CC(C#C)=CC=C4)C=CC=C3)=C1.Cl.Cl
• Target: Apoptosis,Others,Phosphatase,Akt
• Solubility: DMSO:22.5 mg/mL (51.92 mM)

Bioactivity

• In Vivo:
  TD52 dihydrochloride, administered orally at a dosage of 10 mg/kg/day through gavage for a duration of 52 days, significantly reduces the size and weight of MDA-MB-468 xenograft tumors.
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• In Vitro:
  TD52 dihydrochloride, at concentrations ranging from 2 to 10 μM over 48 hours, exhibits an anti-proliferative capacity and triggers differential apoptotic reactions in various cell lines. Specifically, at a concentration of 5 μM for 48 hours, it shows negligible impacts on both p-EGFR and EGFR levels, while notably reducing CIP2A expression. Moreover, across dosages of 2.5, 5, and 7.5 μM for 48 hours, TD52 dihydrochloride progressively induces apoptosis, which is associated with the suppression of CIP2A and p-Akt. Additionally, at a concentration of 5 μM over 24 hours, it considerably enhances the phosphatase activity of PP2A in TNBC cells. At the same 5 μM concentration but extended to 48 hours, TD52 dihydrochloride does not significantly affect other common receptor tyrosine kinases (RTKs), such as IGFR, PDGFR, and VEGFR2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CIP2A, TD 52, TD 52 Dihydrochloride, TD52 2HCl, TD52 Dihydrochloride, TD-52 Dihydrochloride, TD52 dihydrochloride(1798328-24-1 Free base), TD-52, TD52

Compound Identifiers

PubChem CID

164516803