TD034

SKU: orb3136575

Description

TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.

Research Area

Epigenetics & Chromatin, Molecular Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3030718-42-1
• MW: 757.01
• Formula: C₄₅H₆₄N₄O₆
• SMILES: C(CCCCCCCCCC)[C@@H]1[C@@H](C(CCCCC[C@@H]2NC(=O)[C@@]3(N(C(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=CC=C5)NC2=O)CCCC3)[H])=O)O1
• Target: HDAC,YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HDAC,YAP