TCS 21311

SKU: orb1307693

Description

TCS 21311

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1260181-14-3
• MW: 526.51
• Purity: 99.39%
• Formula: C₂₇H₂₅F₃N₄O₄
• SMILES: CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F
• Target: PKC,GSK-3,JAK

Bioactivity

• Target IC50:
  PKCα:13 nM|JAK2:2.55 μM|JAK1:1.017 μM|PKCθ:68 nM|JAK3:8 nM|GSK-3β:3 nM
• In Vitro:
  TCS 21311 displays moderate activity in this cellular assay IC50 689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity. TCS 21311 shows IC50 Values of 1.017, 2.550, and 8.055 μM for JAK1, JAK2, and TYK2, respectively in an enzymatic Jak assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

PKCθ, PKCα, PKC, Protein kinase C, TCS 21311, TCS21311, TCS-21311, NIBR3049, NIBR-3049, NIBR 3049, inhibit, JAK3, Janus kinase, JAK1, JAK2, JAK, Inhibitor, GSK-3, GSK-3β, GSK3, Glycogen synthase kinase 3, Glycogen synthase kinase-3

Compound Identifiers

PubChem CID

50925411