TCL1(10-24)

SKU: orb2563706

Description

TCL1(10-24) is a peptide Akt inhibitor derived from the human TCL1 betaA strand. It functions by blocking the Akt PH domain from binding phosphoinositides, thereby inhibiting Akt membrane translocation and activation. This mechanism suppresses cellular proliferation and promotes apoptosis, demonstrating anti-tumor efficacy in vivo models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• Target: Apoptosis,Akt
• CAS Number: 835655-37-3
• MW: 1871.06
• Formula: C₈₈H₁₂₃N₂₃O₂₃
• SMILES: C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)CCC4)CC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)C)=O)C=6C=7C(NC6)=CC=CC7

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

44561870