TC11

SKU: orb1298384

Description

TC11 is a small molecule research compound that potently inhibits tumor cell proliferation and induces apoptosis through caspase-3, -8, and -9 activation. It is utilized in cancer research for in vitro studies exploring oncogenic pathways and programmed cell death mechanisms.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 100823-03-8
• MW: 322.4
• Purity: 98.10%
• Formula: C₂₀H₂₂N₂O₂
• SMILES: CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccc(N)cc2C1=O
• Target: CDK,Caspase,Bcl-2 Family
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (6.2 mM);DMSO:45 mg/mL (139.58 mM)

Bioactivity

• In Vivo:
  TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11, Caspase, caspase-3, caspase-9, caspase-8, Bcl-2 Family, Antitumor, Apoptotic, Cyclin dependent kinase, Derivative, Death, CDK, CLT 003, CLT003, CLT-003, inhibit, Immunomodulatory, Mitotic, Inhibitor, TC 11, TC11, TC-11, Phenylphthalimide

Compound Identifiers

PubChem CID

1235479