TC-G 1005

SKU: orb1298611

Description

TC-G 1005 is a highly potent and selective GPBA/TGR5 agonist with an EC50 of 0.72 nM, demonstrating oral bioavailability. It shows selectivity over FXR and has been shown in research to elevate plasma GLP-1 and lower blood glucose levels in murine models, supporting its investigation in metabolic disease research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1415407-60-1
• MW: 399.48
• Purity: 99.78% (May vary between batches)
• Formula: C₂₅H₂₅N₃O₂
• SMILES: Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc23)c1
• Target: GPCR19
• Solubility: DMSO:10 mg/mL (25.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.5 mM)

Bioactivity

• Target IC50:
  TGR5 (human):0.72 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, levels, G-protein coupled receptor 19, G protein-coupled Bile Acid Receptor 1, glucose, GPBAR1, GPCR19, hTGR5, inhibit, coupled, TC G 1005, TC-G1005, TC-G-1005, TCG 1005, TC-G 1005, Takeda, protein, TGR5

Compound Identifiers

PubChem CID

71450251