TC-E 5003

SKU: orb1306183

Description

TC-E 5003 (NSC-30176) is a potent and selective PRMT1 inhibitor with an IC50 of 1.5 µM. This compound is a valuable research tool for investigating protein arginine methylation in cancer biology and epigenetics, with utility in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 17328-16-4
• MW: 401.26
• Purity: 97.01% (May vary between batches)
• Formula: C₁₆H₁₄Cl₂N₂O₄S
• SMILES: ClCC(=O)Nc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)CCl)cc1
• Target: PKA,Histone Methyltransferase,NF-κB,DNA/RNA Synthesis
• Solubility: DMSO:45 mg/mL (112.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM)

Bioactivity

• Target IC50:
  PRMT1:1.5 μM
• In Vitro:
  The GI50 values for TC-E 5003 were 1.97 μM on MCF7a cells and 4.49 μM on LNCaP cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-inflammatory, NSC30176, NSC-30176, inhibit, Inhibitor, NSC 30176, hPRMT1, HistoneMethyltransferase, Histone Methyltransferase, TLR4 signaling, PRMT1, TC-E5003, TC-E-5003, TCE 5003, TC-E 5003, TC E 5003

Compound Identifiers

PubChem CID

87052