TC ASK 10

SKU: orb1309026

Description

TC ASK 10

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1005775-56-3
• MW: 432.35
• Purity: 99.86% (May vary between batches)
• Formula: C₂₁H₂₃Cl₂N₅O
• SMILES: Cl.Cl.CC(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-n1ccnc1
• Target: MAPK,Apoptosis,ASK
• Solubility: DMSO:100 mg/mL (231.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.25 mM)

Bioactivity

• Target IC50:
  ASK2:0.51 μM|ASK1:14 nM
• In Vivo:
  In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.
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• In Vitro:
  Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, ASK1, ASK2, bioavailability, oral, inhibit, JNK, Inhibitor, MAP3K, MAP kinase kinase kinase, MEKK, MAPKKK, pharmacokinetic, Phosphorylation, selective, p38, TC ASK 10, TC ASK10, TC ASK-10

Compound Identifiers

PubChem CID

68661090