TbPTR1 inhibitor 1

SKU: orb1688127

Description

TbPTR1 inhibitor 1 (compound 5d) is a potent and selective small molecule inhibitor of Trypanosoma brucei pteridine reductase 1 (TbPTR1), exhibiting an IC50 of <0.1 nM against the enzyme and an EC50 of 0.66 µM against the parasite. This compound is a valuable chemical tool for studying folate metabolism in trypanosomes and for anti-trypanosomal drug discovery research in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2499713-65-2
• MW: 399.45
• Formula: C₂₂H₂₁N₇O
• SMILES: NC=1C2=C(N=C(N)N1)N=CC(CN(CC)C3=CC=C(C(=O)C4=CC=CC=C4)C=C3)=N2
• Target: Others,Parasite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164517153